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EXPERIMENT INFORMATION

Impact of Inflight Stress and Sleep Disturbances on Brain Function, Neural Communication, and Inflammation (80NSSC19K1582)
Principal Investigator
Research Area:
Radiation health
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: C57BL/6
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
OBJECTIVES:
Astronauts may experience several physical and psychological challenges including prolonged exposure to microgravity, potential social isolation (SI), and predicted exposure to ~13 cGy/Yr Space Radiation (SR). Each of these stressors can have deleterious effects on physical and mental health as well as negatively impact mission performance. Each also can disturb sleep, which can further exacerbate the effects of stress. Determining how astronauts respond to the single and compound effects of mission related stressors is crucial for understanding and mitigating factors that could impede mission success. However, examining their effects will be complex because they have different time courses and durations. SR exposure will be episodic whereas microgravity will be constant and SI and sleep disturbances can be temporary or prolonged. Their effects may also be additive or synergistic, and may vary with gender and with individual differences in stress resilience and vulnerability. Therefore, our goal in this project is to determine the single and synergistic effects of inflight stress and SR on mission related biological and functional challenges that astronauts may face.

Aim 1: Effects of SI, HLS and SR on Sleep Architecture, Activity, Stress System Responsivity, Extinction Learning, and Anticipatory Activity.
Aim 2. Determine Synergistic Effects of SR and SI and of SR and HLS on Sleep Architecture, Activity, Stress System Responsivity, Extinction Learning, and Anticipatory Activity.
Aim 3. Determine Synergistic Effects of SR and SI and of SR and HLS on Neural Communication.
Aim 4. Determine Synergistic Effects of SR, SI and HLS on Immune System


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Parameters
Body Composition (DXA)
Body weight
Food intake
Gene Expression Data
Gonad/adipose weight
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
10/02/2019
Proposal Source
2018 HERO 80JSC018N0001-Crew Health and Performance (FLAGSHIP, OMNIBUS). Appendix A-Flagship, Appendix B-Omnibus