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EXPERIMENT INFORMATION

Determining Gender Differences in the Incidence of Lung Adenocarcinoma After Space Radiation Exposure (80NSSC18K1676)
Research Area:
Radiation health
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: BALB/c

Description
OBJECTIVES:
Uncertainties in radiation induced lung cancer risk estimation and its associated mortality rates are among the primary factors limiting the number of safe days an astronaut can spend in space. Initial lung cancer risks are based off epidemiological-based modeling and include cohorts such as the atomic bomb survivor life span study (LSS) whose estimates contain large confidence intervals and whose populations may not reflect astronauts on deep space missions. In order to calculate the permissible exposure limit (PEL) for astronauts it is necessary to collect further information on the risk of lung carcinogenesis due to radiation quality differences (relative biological effectiveness--RBE), sex disparities, and how effective biological countermeasures may reduce or mitigate these risks


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Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

Parameters
Blood/plasma
Enlarged spleens (possible lymphomas)
Liver tumors
Lung tumors
Mammary tumors
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
09/01/2018
Proposal Source
2016-2017 HERO NNJ16ZSA001N-SRHHC. Appendix E: Space Radiobiology and Human Health Countermeasures Topics