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Assessment of Artificial Gravity as a Countermeasure to Cephalad Fluid Shifting (Postdoctoral Fellowship) (NNX16AO69A)
Principal Investigator
Research Area:
Species Studied
Scientific Name: Homo sapiens Species: Human



Despite ongoing research efforts to elucidate the etiology of the Spaceflight Associated Neuro-ocular Syndrome (SANS) and develop potential countermeasures, visual impairment remains a critical risk factor for long-duration human space flight. A growing body of evidence suggests that microgravity-induced cephalad fluids and redistribution of blood volume, especially within the intracranial space, may play a major role in the development of SANS. The goal of this study was to assess the physiological changes related to fluid shifts during a ground-based space flight analog and to assess artificial gravity (AG) via short-arm human centrifugation as a countermeasure against cephalad fluid shifting and ultimately for SANS.

This experiment had the following specific aims:

1) Determine the physiological effects of gravitational vectors through various body positions including head-up tilt, supine and head-down tilt on body fluid distribution as well as cerebral hemodynamic and cardiovascular physiology using novel non-invasive technologies.

2) Determine the effects of short-arm centrifugation on cerebral hemodynamics and full body fluid distribution.

3) Utilize multiple experimental platforms to quantify the ability of AG to reinstate supine and upright fluid distributions as a countermeasure to cephalad fluid shifting.

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Cross-sectional area (CSA)
Intracranial pressure

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source