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Rodent Research 17 (RR-17) (ARC00XX222)
Species Studied
Scientific Name: Mus musculus Species: Mouse Strain: C57BL/6

The Rodent Research-17 (RR-17) investigation utilizes mice flown aboard the International Space Station (ISS), and maintained on Earth, to investigate the physiology of aging in response to microgravity and biological age at onset of the progression of disease. The primary hypothesis of Rodent Research-17 is that exposure to the spaceflight environment accelerates or magnifies the effect of changes observed during the aging process, resulting in significant effects similar to the progression of cellular and metabolic dysfunction associated with aging and senescence on Earth. It is further hypothesized that novel molecular targets may be identified by microgravity exposure that can facilitate the development of treatments related to aging. Furthermore, long-duration exposure to microgravity induces a number of gene expression, protein, and metabolic alterations that may be identifiable as a series of assessable biomarkers for the deleterious effects of aging associated with cellular senescence.

Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
SpaceX_18 07/25/2019 08/27/2019 32 days 22 hours

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Rodent Research Reference Mission 2 (RRRM-2)
Proposal Date
Proposal Source