EXPERIMENT INFORMATION
Head-Down Tilt as a Model for Intracranial and Intraocular Pressures, and Retinal Changes during Spaceflight (NNX13AD94G)
Principal Investigator
Research Area:
Biomedical countermeasures
Species Studied
Scientific Name: Rattus norvegicus Species: Rat
Study Type
Description
OBJECTIVES:
This ground-based program is intended to address the etiology of visual system structural and functional changes observed in astronauts during both inflight and postflight periods. Using the well-documented rat hindlimb suspension (HLS) model, functionally equivalent to human head-down bedrest, we will examine the relationship between cephalic fluid shifts resulting from long-duration G-unloading and the regulation of intracranial and intraocular pressures, as well as the effects these same cephalic fluid shifts have on visual system structure and function.
This ground-based program is intended to address the etiology of visual system structural and functional changes observed in astronauts during both inflight and postflight periods. Using the well-documented rat hindlimb suspension (HLS) model, functionally equivalent to human head-down bedrest, we will examine the relationship between cephalic fluid shifts resulting from long-duration G-unloading and the regulation of intracranial and intraocular pressures, as well as the effects these same cephalic fluid shifts have on visual system structure and function.
Data Availability
Archive is complete. All data sets are on the Web site.
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Parameters
Age
Gender
Pressure, intracranial
Pressure, intraocular
Visual evoked potentials
Mission/Study Information
| Mission | Launch/Start Date | Landing/End Date | Duration |
|---|---|---|---|
| Ground | 05/01/2009 | In Progress |
Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit.
The Human Research Program (HRP) investigates and mitigates the highest risks to human health
and performance, providing essential countermeasures and technologies for human space exploration.
Risks include physiological and performance effects from hazards such as radiation, altered gravity,
and hostile environments, as well as unique challenges in medical support, human factors,
and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify
the approach and research activities planned to address these risks, which are assigned to specific
Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.
The Human Research Roadmap is located at: https://humanresearchroadmap.nasa.gov/
The Human Research Roadmap is located at: https://humanresearchroadmap.nasa.gov/
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Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
10/01/2012
Proposal Source
2011 Crew Health NNJ11ZSA002NA