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EXPERIMENT INFORMATION

Histochemistry of Hypothalamus (SLS1 BSP17)
Principal Investigator
Research Area:
Neurophysiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

Previous analysis of the anterior hypothalamus and the anterior lobe of the pituitary gland of rats flown on Cosmos biosatellites and Spacelab-3 revealed inhibition of the synthesis and excretion of growth hormone, and the system controlling these processes. This experiment was to assess spaceflight effects on the GABA (gamma-aminobutyric acid) and other enzymes in the system of the hypothalamus.


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Publications
Fidelina OV, Corbatyuk OS, Krasnov IB, Akmayev IG: Reactions of the hypothalamic paraventricular nucleus and vagus nerve dorsalis nucleus in the rats exposed to changed gravitational environment [in Russian]. Probl. Endocrin., vol. 41(6), 1995, pp. 35-38.

Krasnov IB, Fidelina OV, Gorbatiuk OS, Vikhreva OV. Repeated exposure in hypergravity: morphology of locus coeruleus, hypothalamic paraventricular nucleus and vagal nerve dorsal nucleus in rats. Aviakosm Ekolog Med. 2000;34(3):21-7

Sergutina AV, Gershtein LM, D'Amelio FD, Donton N, Krasnov IB: Some cytochemical features of the motor system of the rat brain after spaceflight. Biull Eksp Biol Med, vol. 119(3) , Mar 1995, pp. 288-290.

Keywords
GABA
Hypothalamus
Enzymes

Data Information
Data Availability
Archiving in Progress. Some data exist for this experiment.
Data Sets+ View data

Parameters
Activity, enzymic, Glutaminase, hypothalamus, brain, rat, Histochemical
Activity, motor, Rat, Microgravity, SLS-1 (counts)
Defatted tissue: hypothalamus
Gamma-aminobutyric acid (GABA): hypothalamus
Glutamate: hypothalamus
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-40 06/05/1991 06/14/1991 9 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
Russian Space Agency (RSA)
Protocol / Approach
Synchronous control
125I-Albumin
51Cr-red cells
59Fe-Citrate
Calcein
Demeclocycline
Vivarium control
3H-Proline