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EXPERIMENT INFORMATION

Bio-Assay of Body Fluids (M073)
Principal Investigator
Research Area:
Endocrinology
Metabolism and nutrition
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
The space flight environment with its combination of stresses offers a unique challenge to the body’s biochemical control mechanisms. Astronauts returning from Gemini and Apollo flights demonstrated biochemical changes of sufficient magnitude and complexity to warrant detailed studies of the endocrine and metabolic systems. The Bio-Assay of Body Fluids (M073) experiment was designed to study homeostasis in the areas of (1) fluid and electrolyte balance, (2) regulation of calcium metabolism, (3) adrenal function, and (4) carbohydrate, fat, and protein utilization. The study was divided into two broad categories. One category included routine blood and urine studies similar to those used in clinical medical practice. The second category included a more thorough analyses to investigate the metabolic/endocrine responses to the space flight environment, including fluid and electrolyte control mechanisms.


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Publications
Johnston RS and Dietlein LF. Medical results of the Skylab program. International Astronautical Federation, International Astronautical Congress; 25th; Sept. 30, 1974-Oct. 5, 1974; Amsterdam; Netherlands. September 01, 1974. Conference Paper.

Johnston RS and Dietlein LF. Medical Support and Findings of the Skylab Program. NASA Johnson Space Center; Houston, TX, United States. March 01, 1975. NASA-TM-X-58160. [NTRS]

Leach CS and Rambaut PC. Bioassay of body fluids, experiment M073. NASA Johnson Space Center; Houston, TX, United States. October 01, 1973. Technical Report.

Leach CS, Rambaut PC. Biochemical responses of the Skylab crewmen. In: Johnston RS, Dietlein LF, editors. The Proceeding of the Skylab Life Sciences Symposium; 1974 Aug 27-29; National Aeronautics and Space Administration (NASA):Houston (TX). Report No: TM X-58154. [NTRS]

Leach CS, Rambaut PC. Biochemical responses of the Skylab crewmen: an overview. In: Johnston RS, Dietlein LF, editors. Biomedical results from Skylab. Washington, D.C: NASA, 1977:204-216. NASA SP-377. [NTRS]

Leach CS. An overview of the endocrine and metabolic changes in manned space flight. Acta Astronautica. 1981. Sepember-October; 8(9-10):977-86. [pubmed.gov]

Rambaut PC, Leach CS, and Leonard JI. Observations in energy balance in man during spaceflight. American Journal of Physiology. 1977. November; 233(5):R208-12. [pubmed.gov]

Keywords
Metabolism
Cadmium
Carbon dioxide (CO2)
Creatine

Photo Gallery
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Data Information
Data Availability
Archive is complete. Data sets are not publicly available but can be requested.
Data Sets+ Request data

Parameters
17 hydroxycorticosteroids
Adrenocorticotropic hormone ACTH
Albumin
Aldosterone
Aldosterone in plasma
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Skylab 2 05/25/1973 06/22/1973 28 days
Skylab 3 07/28/1973 09/25/1973 59.5 days
Skylab 4 11/16/1973 02/08/1974 84 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Eric Gallagher
Institutional Support
National Aeronautics and Space Administration (NASA)