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EXPERIMENT INFORMATION

Cytogenetic Studies of Blood (M111)
Principal Investigator
Research Area:
Cell and molecular biology
Radiation biology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
It has been established that increased frequency of chromosomal aberrations occurs in humans following exposure to ionizing radiation. Information has been obtained by studying persons exposed to a radiation source external to the body, such as by therapeutic dosage, or of those accidentally exposed. Others receiving radiation exposure from an internal source, such as the decay of radioisotopes administered for diagnosis or treatment, have also been studied. Concern regarding the development of cancer in irradiated human populations has been suggested by scientific studies. Therefore, cytogenetic studies were important in manned space flight with regard to the known health risks of radiation exposure. Skylab studies examined the effects of ionizing radiation exposure on human cells during long duration missions. The objective of this experiment was to determine whether the radiation exposure that crewmembers were subject to during the Skylab mission increased the frequency of chromosomal aberrations in human lymphocytes.


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Publications
BioTechnology, Inc, ed. Skylab Medical Experiments Altitude Test (SMEAT). Springfield, Va: Clearinghouse for Federal Scientific and Technical Information; 1973.NASA-TM-X-58115. [NTRS]

Lockhart LH, Cytogenetic studies of blood. Proceedings of the Skylab Life Sciences Symposium August 27-29, 1974. National Aeronautics and Space Administration, Johnson Space Center; 1974; 763-774. Report No: JSC-09275, Report No: TM X-58154. [NTRS]

Lockhart LH. Cytogenetic studies of blood. In: Johnston RS, Dietlein LF, eds. Biomedical Results from Skylab. Washington, DC: NASA Headquarters; 1977. NASA SP-377. [NTRS]

Keywords
Chromosome breakage
Chromosomes
Cytogenetics

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Data Information
Data Availability
Archive is complete. Some data sets are online.
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Parameters
Cell count
Chromosome breakage
Chromosome defects
Chromosome structural rearrangement translocations
Chromosome structural rearrangement dicentrics
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Skylab 2 05/25/1973 06/22/1973 28 days
Skylab 3 07/28/1973 09/25/1973 59.5 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Eric Gallagher
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
SMEAT