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EXPERIMENT INFORMATION

Man's Immunity In-vitro Aspects (M112)
Research Area:
Immunology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
During early manned space flights scientists were concerned that the immune system would be compromised from the lack of exposure to multiple immunological challenges. Astronauts could be repeatedly exposed to the same antigen. Therefore, the closed environment of the spacecraft module might increase the susceptibility to infections. Results from the Apollo Program indicated that an acute-phase response of immunological proteins might be characteristic of space flight. Therefore, the immunological integrity of Skylab crewmembers was assessed for the medical risks of manned space flight. The experiment objectives were to (1) assess the status of crew health prior to the launch of each mission, (2) establish individual baseline data for later comparisons and (3) detect possible aberrations of the immune system as a result of exposure to space flight. The functional objectives of this experiment were to (1) measure changes in humoral and cellular immunity as reflected by the concentrations of plasma and blood cell proteins, blastoid transformations, synthesis of ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) by the lymphocytes and (2) to acquire data that will add to the findings of other Skylab biomedical experiments to yield a greater comprehension of the affects that space travel has on man.


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Publications
Kimzey SL, Johnson PC, Ritzman SE, Mengel CE. Hematology and immunology studies: the second manned skylab mission. Aviat Space Environ Med. 1976 47(4):383-390. [pubmed.gov]

Kimzey SL, Ritzmann SE, Mengel CE, Fischer CL. Skylab experiment results: hematology studies. Acta Astronautica 2:141-154, 1975.

Kimzey, SL. Hematology and immunology studies. In: Johnston RS, Dietlein LF, eds. Biomedical Results from Skylab. Washington, DC: NASA Headquarters; 1977:249-282. NASA SP-377. [NTRS]

Keywords
Blood cell count
Blood proteins
Cell division
DNA
IgA
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Data Information
Data Availability
Archive is complete. Data sets are not publicly available but can be requested.
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Parameters
Albumin: plasma
Alpha1-Acid Glycoprotein: plasma
Alpha1-antichymotrypsin: plasma
Alpha1-antitrypsin: plasma
Alpha2-Globulin: plasma
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Skylab 2 05/25/1973 06/22/1973 28 days
Skylab 3 07/28/1973 09/25/1973 59.5 days
Skylab 4 11/16/1973 02/08/1974 84 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Eric Gallagher
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
RME-3