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Absence of Gastric Ulceration in Rats After Flight on the Cosmos 782 (COS 782-5)
Principal Investigator
Research Area:
Metabolism and nutrition
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar


A variety of environmental stressors can be shown to produce gastric ulceration in rats. Several converging lines of research have shown that endogenous histamine plays an essential role in stress-produced gastric ulceration. It has been demonstrated, as well, that the mechanism specifically involves the H2 receptor for histamine. Whether the actual stresses associated with a long-term space flight are sufficient to produce gastric ulceration in rats is uncertain, and the focus of this study.

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Brown, P.A. and J. Vernikos-Danellis: Absence of Gastric Ulceration in Rats After Flight on the Cosmos 782. Final Reports of U.S. Experiments Flown on the Soviet Satellite Cosmos 782. S.N. Rosenzweig and K.A. Souza, eds., NASA TM-78525, 1978, pp. 200-206.

Brown, P.A. et al.: Attenuation of Salicylate and Stress-Produced Gastric Ulceration by Metiamide. Proceedings of the Western Pharmacology Society, vol. 18, 1975, pp. 123-127.

Brown, P.A. et al.: Histamine H2 Receptor: Involvement in Gastric Ulceration. Life Sciences, vol. 18, 1976,
pp. 339-344.

Gastric mucosa
Stomach ulcer

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Content, Enzymes, Gastric/ digestive (stomach)
Damage, Ulcer, gastric, rat, Microscopic (descriptive)
Damage, Ulcer, petechial, gastric, rat, Microscopic (no units)
Damage, Ulcer, punctate, gastric, rat, Microscopic (descriptive)
Morphology, Mucus membrane, gastric (stomach), rat, Microscopic (no units)

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 782 11/25/1975 12/15/1975 20 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Protocol / Approach
Hardware Items