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Effects of Spaceflight on Plasma and Glandular Concentrations of Pituitary Hormones (COS 782-13)
Research Area:
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar


The important role played by hormones in regulation of metabolic parameters affected by space flight suggests that altered endocrine function may have contributed to other observed metabolic changes. The aims of the present study were to clarify the effects of space flight on pituitary function by measuring plasma and glandular concentrations of pituitary hormones and, where feasible, evaluating the status of the appropriate target tissue.

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Ellis, S. and R.E. Grindeland: Dichotomy Between Bioassayable and Immunoassayable Growth Hormone. Advance in Human Growth Hormone Research, S. Raiti, ed., National Institute of Arthritis, Metabolism, and Digestive Diseases, DHEW Pub. No. (NIH)74-612, 1974, pp. 409-433.

Grindeland, R.E.: Effects of Spaceflight on Plasma and Glandular Concentrations of Pituitary Hormones. Final Reports of U.S. Experiments Flown on the Soviet Satellite Cosmos 782. S.N. Rosenzweig and K.A. Souza, eds., NASA TM-78525, 1978, pp. 253-275.

Grindeland, R.E.: Space Weightlessness and Hormonal Changes in Humans and Experimental Animals. Space Gerontology, vol. 6, 1982, pp. 55-57.

Keil, L.C. and W.B. Severs: Reduction in Plasma Vasopressin Levels of Dehydrated Rats Following Acute Stress. Endocrinology, vol. 100, 1977, pp. 30-38.

Adrenal glands
Corticotropin (ACTH)
Pituitary gland
Pituitary hormones
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Composition, Hematocrit, blood, rat, clinical laboratory
Content, hormone, Adrenocorticotrophic hormone (ACTH), plasma, rat, Immunoassay
Content, hormone, Prolactin, plasma, rat, Immunoassay
Content, Prolactin (PRL), pituitary, rat, Histochemistry, fluorescence, cell culture, radioimmunoassay
Content, Thyrotropin, pituitary, rat, Double antibody method
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 782 11/25/1975 12/15/1975 20 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Protocol / Approach