Skip to page content Mission Information

EXPERIMENT INFORMATION

Effect of Spaceflight on Cell-Mediated Immunity (COS 782-9)
Principal Investigator
Research Area:
Immunology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

It has been demonstrated that cell-mediated immune reactions in mammals are thymus-dependent, and that thymus-derived or thymus-dependent lymphocytes (T-cells) are responsible for the reactions of cellular immunity. Rats flown in Cosmos 605 have shown changes in the size of thymus and spleen, suggesting that space flight might have a noticeable effect on the cellular aspect of immune responsiveness. This study examined the effect of space flight on cell-mediated immunity by examining rats infected with Listeria monocytogen.


++ -- View more

Publications
Mandel, A.D. and E. Balish: Effect of Spaceflight on Cell-Mediated Immunity. Aviation, Space, and Environmental Medicine, vol. 48, 1977, pp. 1051-1057.

Mandel, A.D. and E. Balish: Effect of Spaceflight on Cell-Mediated Immunity: Final Reports of U.S. Experiments Flown on the Soviet Satellite Cosmos 782. S.N. Rosenzweig and K.A. Souza, eds., NASA TM-78525, 1978, pp. 207-226.

Marra, S. and E. Balish: Immunity to Candida Albicans Induced by Listeria Monocytogenes. Infectional Immunology, vol. 10, 1974, pp. 72-82.

Sonnenfeld, G. et al.: Immune Changes in Test Animals During Spaceflight. Journal of Leukocyte Biology, vol. 54, no. 3, 1993, pp. 214-226.

Keywords
Antigens, bacterial
Concanavalin A
Freund's adjuvant
Immunity, cellular
Listeria infections
++ -- View more

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Radiation (uptake), Thymidine incorporation, tritiated, lymphocytes, Radiochemistry, Counter (activity units)
Response, Immune system, spleen culture cells, to mitogen challenge, rat, 3H-thymidine uptake
Response, Immune, spleen culture cells, to listeria challenge, rat, 3H-thymidine uptake

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 782 11/25/1975 12/15/1975 20 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C782-3.1
Protocol / Approach
Hardware Items