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Bioreactor Flow and Particle Trajectory in Microgravity (DSO 316)
Principal Investigator
Research Area:
Cell and molecular biology
Technology development

Investigators at Johnson Space Center (JSC) performed a hardware test on the Bioreactor systems to evaluate possible cell growth in microgravity. Cell growth has been used as an indicator for toxic conditions for years. Cells can be grown in the Bioreactor systems. Combining these conditions identified specific toxic compounds in the Shuttle atmosphere and their biological impact. A Biotechnology goal was to provide sensitive mammalian toxicological testing on short-duration flights that identified potential long-duration hazards.

Development of the Bioreactor systems proposed for use in the Space Station depended on understanding the fluid dynamics of such systems in microgravity. This equipment test permitted the comparison of actual microgravity particle trajectories in the rotating vessel, with calculated trajectories, thus providing data required to improve or modify the systems.

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Tsao YD, Goodwin TJ, Wolf DA, Spaulding GF. Responses of gravity level variations on the NASA/JSC bioreactor system. Physiologist. 1992 Feb;35(1 Suppl):S49-50. []

Ingram M, Techy GB, Saroufeem R, Yazan O, Narayan KS, Goodwin TJ, Spaulding GF. Three-dimensional growth patterns of various human tumor cell lines in simulated microgravity of a NASA bioreactor. In Vitro Cell Dev Biol Anim. 1997 Jun;33(6):459-66. []

Radiation effects
Cell size

Photo Gallery
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Bioreactor variables
Cell growth
Fluid flow
Particle trajectories

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-44 11/24/1991 12/01/1991 7 days
STS-54 01/13/1993 01/19/1993 6 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Jessica Keune
Institutional Support
National Aeronautics and Space Administration (NASA)