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EXPERIMENT INFORMATION

Quantitative Analysis of Selected Bone Parameters (COS 782-11)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

If bones are formed in relation to gravitational stresses, one would anticipate that prolonged recumbency and/or prolonged weightlessness would be associated with hypercalciuria, bone demineralization, and osteoporosis. To better understand the effect of space flight on bone, parameters including formation and mineralization, resorption, length, density and pore size distribution, and bone mechanical properties were studied in rats both immediately postflight and at 25 days post- flight.


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Publications
Holton, E.M.: Effects of Weightlessness on Bone and Muscle of Rats. Space Gerontology, NASA CP-2248, 1982, pp. 59-66.

Morey, E.R. and D.J. Baylink: Inhibition of Bone Formation During Spaceflight. Science, vol. 201, 1978,
pp. 1138-1141.

Morey-Holton, E. and D.J. Baylink: Quantitative Analysis of Selected Bone Parameters: Final Reports of U.S. Experiments Flown on the Soviet Satellite Cosmos 782. S.N. Rosenzweig and K.A. Souza, eds., NASA TM-78525, 1978, pp. 321-351.

Keywords
Biomechanics
Bone density
Bone development
Bone resorption
Calcification, physiologic
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Area, Bone, tibia, rat, Microscopy
Area, cross section, Tibia, rat
Density, Femur, bone, rat, Mercury porosimetry (relative)
Formation, Bone, in femur, rat, Merz grid, microscopy, chemistry
Size, length, Bone, femur, rat, Caliper
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 782 11/25/1975 12/15/1975 20 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C782-6
Protocol / Approach
Hardware Items