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EXPERIMENT INFORMATION

Inflight Salivary Pharmacokinetics of Scopolamine and Dextroamphetamine (DSO 457)
Principal Investigator
Research Area:
Clinical medicine
Neurophysiology
Pharmacology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
Pharmacologic studies of therapeutic agents used by astronauts during space flight need to be performed to compare drug bioavailability and effectiveness during weightlessness with those characteristics under 1-g conditions. To determine the applicability of noninvasive salivary drug monitoring for pharmacokinetic evaluation of therapeutic agents during space flight, three drugs that are frequently used by crewmembers have been selected for in flight study - acetaminophen, a relatively innocuous, common pain relief medication whose disposition characteristics have been well established, and a scopolamine/dextroamphetamine combination, an operational medication used for the treatment of space motion sickness during missions. The feasibility of such an application for salivary drug monitoring depends upon the distribution of detectable levels of the drug into saliva and the establishment of a consistent saliva/plasma (S/P) ratio over the entire disposition profile of the drug.

Ground-based investigations to establish the S/P ratios of scopolamine have been conducted in normal subjects. Following intravenous and oral administration, scopolamine readily distributes into saliva with consistent S/P ratios over the entire disposition profile. In this investigation, the pharmacokinetics of scopolamine/dextroamphetamine following oral administration to crewmembers before and during space flight were evaluated using salivary concentrations to estimate the disposition parameter changes of anti-motion sickness agents during missions.


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Publications
Cintron NM, Putcha L, Vanderploeg JM. Inflight salivary pharmacokinetics of scopolamine and dextroamphetamine. In: Bungo MW, Bagian TM, Bowman MA, Levitan BM, editors. Results of the life sciences DSOs conducted aboard the Space Shuttle 1981-1986. Houston: Space Biomedical Research Institute, Johnson Space Center, 1987:25-9. [NTRS]

Keywords
Absorption
Biological availability
Dextroamphetamine
Pharmacokinetics
Saliva
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Data Information
Data Availability
Archive is complete. Data sets are not publicly available but can be requested.
Data Sets+ Request data

Parameters
Dextroamphetamine
Salivary concentration-time
Scopolamine

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-26 09/29/1988 10/03/1988 4 days
STS-28 08/08/1989 08/13/1989 5 days
STS-29 03/13/1989 03/18/1989 5 days
STS-30 05/04/1989 05/08/1989 4 days
STS-32 01/09/1990 01/20/1990 11 days
STS-34 10/18/1989 10/23/1989 5 days
STS-61B 11/26/1985 12/03/1985 7 days
STS-61C 01/12/1986 01/18/1986 6 days

Additional Information
Other Key People
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Pamela A. Bieri
Institutional Support
National Aeronautics and Space Administration (NASA)
Hardware Items