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Pre- and Postflight Cardiac Assessment (DSO 466)
Principal Investigator
Research Area:
Cardiovascular physiology
Species Studied
Scientific Name: Homo sapiens Species: Human

Space flight causes adaptive changes in cardiovascular function, and many astronauts have suffered postflight orthostatic tachycardia. However, previously available data about these changes have been inadequate and inconsistent. The objective of this study was to collect normative data about the effects of space flight on the volume, mass and function of the heart, and about the orthostatic response of the cardiovascular system.

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Charles JB, Bungo MW, Mulvagh SL. DSO 466: Pre- and postflight cardiovascular assessment/interim report. In: Results of the life sciences DSOs conducted aboard the Space Shuttle 1988-1990. Houston: NASA Johnson Space Center, 1991:9-19.

Charles JB, Fritsch-Yelle JM, Whitson PA, Wood ML, Brown TE, Fortner GW. Cardiovascular deconditioning. In: Sawin CF, Taylor GR, Smith WL, editors. Extended Duration Orbiter Medical Project final report 1989-1995. Houston: NASA Johnson Space Center, 1999:1-1--1-19.

Charles JB, Lathers CM. Cardiovascular adaptation to spaceflight. J Clin Pharmacol 1991;31:1010-23.

Lathers CM, Charles JB, Bungo MW. Comparison of cardiovascular function during head-down bedrest and space flight. J Clin Pharmacol 1991;31:842 (Abstract).

Lathers CM, Charles JB, Elton KF, Holt TA, Mukai C, Bennett BS, Bungo MW. Hemodynamic changes in brief weightlessness. J Clin Pharmacol 1989;29:833 (Abstract).

Lathers CM, Charles JB, Mukai CN, Riddle JM, Jacobs FO, Bennett BS, Lewis D, Fortney S, Frey MAB, Stricklin MD, Schneider VS. Use of lower body negative pressure (LBNP) to assess changes in orthostatic heart rate response during 17 weeks of bedrest. J Clin Pharmacol 1994 Jun;34(6):563-70.

Lathers CM, Charles JB. Autonomic orthostatic hypotension (OH) in patients and bedrest subjects. J Clin Pharmacol 1994;34(5):403-17.[]

Mukai CN, Lathers CM, Charles JB, Bennett BS, Igarashi M, Patel S. Acute hemodynamic responses to weightlessness during parabolic flight. J Clin Pharmacol 1991;31:993-1000.

Mukai CN, Lathers CM, Charles JB, Bennett BS, Igarashi M, Patel S. Acute hemodynamic responses to weightlessness during parabolic flight. J Clin Pharmacol 1991;31:993-1000.[]

Mulvagh SL, Charles JB, Riddle JM, Rehbein TL, Bungo MW. Echocardiographic evaluation of the cardiovascular effects of short-duration spaceflight. J Clin Pharmacol 1991;31:1024-6.[]

Simanonok KE, Charles JB. Space sickness and fluid shifts: a hypothesis. J Clin Pharmacol 1994;34:652-63.[]

Autonomic nervous system
Blood pressure
Body fluids
Cardiac volume
Cardiovascular system
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Data Information
Data Availability
Archive is complete. Data sets are not publicly available but can be requested.
Data Sets+ Request data

Aortic root
Body position
Body surface area
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-26 09/29/1988 10/03/1988 4 days
STS-27 12/02/1988 12/06/1988 4 days
STS-28 08/08/1989 08/13/1989 5 days
STS-29 03/13/1989 03/18/1989 5 days
STS-30 05/04/1989 05/08/1989 4 days
STS-31 04/24/1990 04/29/1990 5 days
STS-32 01/09/1990 01/20/1990 11 days
STS-33 11/22/1989 11/27/1989 5 days
STS-34 10/18/1989 10/23/1989 5 days
STS-35 12/02/1990 12/11/1990 9 days
STS-36 02/28/1990 03/04/1990 4 days
STS-39 04/28/1991 05/06/1991 8 days
STS-42 01/22/1992 01/30/1992 8 days

Additional Information
Other Key People
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Jessica Keune
Institutional Support
National Aeronautics and Space Administration (NASA)
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