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EXPERIMENT INFORMATION

Muscle Biopsy (DSO 475)
Research Area:
Muscle physiology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
The skeletal muscle atrophy that occurs in response to microgravity is manifested as microscopic changes in muscle morphology and as changes in muscle function. The objective of this study was to define the morphologic and biochemical changes.


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Publications
Day MK, Allen DL, Mohajerani L, Greenisen MC, Roy RR, Edgerton VR. Adaptations of human skeletal muscle fibers to spaceflight. Journal of Gravitational Physiology. 1995;2 (1):47-50.[pubmed.gov]

Edgerton VR, Zhou M-Y, Ohira Y, Klitgaard H, Jiang B. Bell G, Harris B, Saltin B, Gollnick PD, Roy RR, Day MK, Greenisen M. Human fiber size and enzymatic properties after 5 and 11 days of spaceflight. Journal of Applied Physiology. 1995;78:1733-9.[pubmed.gov]

Greenisen MC, Hayes JC, Siconolfi SF, Moore AD. Functional performance evaluation. In: Sawin CF, Taylor GR, Smith WL, editors. Extended Duration Orbiter Medical Project final report 1989-1995. Houston: NASA Johnson Space Center, 1999:3-1--3-24.

Moore AD Jr, Charles JB, Lee SMC, Siconolfi SF, Greenisen MC. Does bed rest produce changes in orthostatic function comparable to those induced by space flight? Acta Astronautica. 1994;33:57-67.[pubmed.gov]

Zhou MY, Klitgaard H, Saltin B, Roy RR. Edgerton VR. Gollnick PD. Myosin heavy chain isoforms of human muscle after short-term spaceflight. Journal of Applied Physiology. 1995;78:1740-9.[pubmed.gov]

Keywords
Adenosinetriphosphatase (ATPase)
Antibodies, monoclonal
Atrophy
Blotting, western
Capillaries
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Data Information
Data Availability
Archive is complete. Some data sets are online.
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Some data sets are not publicly available but can be requested.
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Parameters
Cross-sectional area
Fiber number
Fiber type
GPD activity
Myofibrillar ATPase activity
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-32 01/09/1990 01/20/1990 11 days
STS-33 11/22/1989 11/27/1989 5 days
STS-34 10/18/1989 10/23/1989 5 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Pamela A. Bieri
Institutional Support
National Aeronautics and Space Administration (NASA)
Hardware Items