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Cardiovascular Responses to Lower Body Negative Pressure Following Space Flight (DSO 607)
Research Area:
Cardiovascular physiology
Species Studied
Scientific Name: Homo sapiens Species: Human

Orthostatic intolerance is a significant safety concern for Shuttle crew members during return to a 1-g environment and in cases of emergency egress. Orthostatic intolerance may result from decreased body hydration, increased leg compliance, or impaired cardiac or vascular compensatory response. Lower body negative pressure (LBNP) introduces a simulated orthostatic stress in a gradual and graded manner and it was used to test the orthostatic function of crew members before and after flight.

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Greenisen MC, Hayes JC, Siconolfi SF, Moore AD. Functional performance evaluation. In: Sawin CF, Taylor GR, Smith WL, editors. Extended Duration Orbiter Medical Project final report 1989-1995. Houston: NASA Johnson Space Center, 1999.

Autonomic nervous system
Blood pressure
Body water
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Data Information
Data Availability
Archive is complete. Data sets are not publicly available but can be requested.
Data Sets+ Request data

Arterial occlusive disease AOD
Body surface area
Body weight
Cardiac arrhythmia syndrome CAS
Cardiac index
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-37 04/05/1991 04/11/1991 6 days
STS-39 04/28/1991 05/06/1991 8 days
STS-43 08/02/1991 08/11/1991 9 days
STS-44 11/24/1991 12/01/1991 7 days
STS-45 03/24/1992 04/02/1992 9 days
STS-47 09/12/1992 09/19/1992 7 days
STS-50 06/25/1992 07/09/1992 14 days
STS-52 10/22/1992 11/01/1992 10 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Pamela A. Bieri
Institutional Support
National Aeronautics and Space Administration (NASA)