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EXPERIMENT INFORMATION

Effect of Weightlessness and Centrifugation (1xG) on Erythrocyte Survival in Rats Subjected to Prolonged Spaceflight (COS 936-4)
Principal Investigator
Research Area:
Hematology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

With few exceptions, the loss of a variable quantity of red blood cell (RBC) mass has been a consistent finding in humans subjected to space flight. Past data suggest that mechanisms other than oxygen-induced hemolysis must be operative to cause this decrease in RBC mass. Analysis of Cosmos 782 data showed that random hemolysis was increased three-fold in the flight rats and the mean potential life span was decreased about 5%. The present experiment was undertaken to verify the alterations seen in Cosmos 782 and to ascertain if the alterations could be attenuated by artificial gravity via an onboard centrifuge.


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Publications
Leon, H.A. et al.: Effect of Weightlessness and Centrifugation (1xG) on Erythrocyte Survival in Rats Subjected to Prolonged Spaceflight. Final Reports of U.S. Experiments Flown on the Soviet Satellite Cosmos 936.
S.N. Rosenzweig and K.A. Souza, eds., NASA TM-78526, 1978, pp. 60-77.

Leon, H.A. et al.: Effect of Weightlessness and Centrifugation on Red Blood Cell Survival in Rats Subjected to Spaceflight. Aviation, Space, and Environmental Medicine, vol. 51, 1980, pp. 1091-1094.

Keywords
Carbon dioxide (CO2)
Carbon monoxide
Erythrocyte aging
Erythrocytes
Fluid shifts
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Carbon dioxide output
Cell metabolism: erythrocytes, Rat, Biochemical
Count, Red blood cells (RBC), peripheral blood, rat, Clinical laboratory
Glycine
Hemolysis
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 936 08/03/1977 08/22/1977 19 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C936-1
Protocol / Approach