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EXPERIMENT INFORMATION

Gastrointestinal Function During Extended Duration Space Flight (DSO 622)
Principal Investigator
Research Area:
Gastrointestinal physiology
Species Studied
Scientific Name: Homo sapiens Species: Human

Description
OBJECTIVES:
The absence of gravity might reduce gastrointestinal motility (the smooth muscle action that mixes the food and propels it through the gastrointestinal tract), which could decrease appetite and absorption of fluids, nutrients, and medications. The objective of this study was to evaluate the effect of space flight on the gastric emptying rate and intestinal transit time.


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Publications
Greenisen MC, Hayes JC, Siconolfi SF, Moore AD. Functional performance evaluation. In: Sawin CF, Taylor GR, Smith WL, editors. Extended Duration Orbiter Medical Project final report 1989-1995. Houston: NASA Johnson Space Center, 1999.

Lane HW, LeBlanc AD, Putcha L, and Whitson PA. Nutrition and human physiological adaptations to space flight. The American Journal of Clinical Nutrition. 1993 Nov; 58(5):583-8. [pubmed.gov]

Lane HW, Whitson PA, Putcha L, Baker E, Smith SM, Stewart K, Gretebeck RJ, Nimmagudda RR, Schoeller DA, Davis-Street J, Pietrzyk RA, DeKerlegand DE, Pak CYC, and Bourne DWA. Regulatory Physiology. In: Sawin CF, Taylor GR, Smith WL, editors. Extended Duration Orbiter Medical Project final report 1989-1995. Houston: NASA Johnson Space Center, 1999.

Nimmagudda RR, Ramanathan R, and Putcha L. A method for preserving saliva samples at ambient temperatures. Biochemical Archives. 1997 Aug; 13(3):171-8. [pubmed.gov]

Tietze KJ,and Putcha L. Factors affecting drug bioavailability in space. Journal of Clinical Pharmacology. 1994 Jun; 34(6):671-6. [pubmed.gov]

Keywords
Acetaminophen
Biological availability
Drug stability
Gastrointestinal system
Lactulose
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Data Information
Data Availability
Archive is complete. Data sets are not publicly available but can be requested.
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Parameters
Acetaminophen metabolites
Acetaminophen, salivary
Acetaminophen, urinary
Glucuronide, urinary
Sulfate, urinary

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-51 09/12/1993 09/22/1993 10 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Pamela A. Bieri
Institutional Support
National Aeronautics and Space Administration (NASA)