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Rhesus Monkey Metabolism During Space Flight: Measurement of Energy Expenditure Using the Doubly Labeled Water (2H2 18O DLW) Method (8809A09)
Principal Investigator
Research Area:
Metabolism and nutrition
Species Studied
Scientific Name: Macaca mulatta Species: Monkey Strain: Rhesus


In theory, the energy requirements of larger mammals should be decreased in the microgravity spaceflight environment. The objective of this study was to determine the effect of spaceflight on mean daily energy expenditure in rhesus monkeys.

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Fuller CA, Stein TP, Griffin DW, Dotsenko MA, Korolkov VI. Rhesus monkey metabolism during spaceflight: measurement of energy expenditure using the doubly labeled water method. Final Reports of the US Experiments Flown on the Soviet Biosatellite Cosmos 2229, Apr 1997.

Stein TP, Dotsenko MA, Korolkov VI, Griffin DW, Fuller CW. Energy expenditure in rhesus monkeys (Macaca mulatta) during spaceflight using doubly labeled water. Journal of Applied Physiology, July 1996, 81(1):201-207.

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Activity, Carbon dioxide production, primate, Doubly labeled water (2H218O) method
Content, total body water, Primate, Urine, double isotope method, mass spectrograph
Isotope, 18 Oxygen (18O), loss in exhale (carbon dioxide) and urine, primate, Calculated
Isotope, Deuterium (2H), loss in urine (water), primate, Mass spectrograph
Response, energy expenditure, Urine/exhalation measurements, primate: Double isotope method, Mass spectrograph

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2229 12/29/1992 01/10/1993 12 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Protocol / Approach
Vivarium control
Synchronous control
Proposal Date
Proposal Source
Hardware Items