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EXPERIMENT INFORMATION

Quantitative Analysis of Selected Bone Parameters: Formation of Ectopic Bone in Implanted Matrices (COS 936-1)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Undenatured bone matrix, demineralized and lyophilized, induces bone formation when implanted in muscle or fascia of host animals. This model was employed by Soviet scientists to evaluate the effects of space flight on bone formation in implanted matrices. Approximately half the implanted matrices recovered from basal, synchronous, vivarium control, and flight groups of rats were sent to the U.S. for independent evaluation. These were accompanied by samples of unimplanted bone matrix.


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Publications
Baylink, D.J. et al.: Quantitative Analysis of Selected Bone Parameters: Formation of Ectopic Bone in Implanted Matrices. Final Reports of U.S. Experiments Flown on the Soviet Satellite Cosmos 936. S.N. Rosenzweig and K.A. Souza, eds., NASA TM-78526, 1978, pp. 179-183.

Keywords
Bone density
Bone development
Bone mineralization
Bone resorption
Calcification, physiologic
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Bone formation
Bone matrix
Bone, ectopic
Bone, implanted bone
Content, Calcium, bone, ectopic implanted, rat, Atomic absorption spectrophotometry (μg Ca/mg dry weight)
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 936 08/03/1977 08/22/1977 19 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C936-2.2
Protocol / Approach