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EXPERIMENT INFORMATION

Rhesus Monkey Immunology Study (COS 2229-2)
Principal Investigator
Research Area:
Immunology
Species Studied
Scientific Name: Macaca mulatta Species: Monkey Strain: Rhesus

Description
Objectives:

This experiment on the Cosmos 2229 mission was designed to begin to determine the suitability of the rhesus monkey as a surrogate for humans in space immunology research. Two tests were carried out to examine the effects of spaceflight on the capacity to resist infection. One tested the responsiveness of rhesus bone marrow cells to recombinant human granulocyte/macrophage colony stimulating factor (GM-CSF). The other test used blood and bone marrow cells to examine microgravity-induced changes in staining patterns against a variety of antibodies.


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Publications
Lesnyak AT, Sonnenfeld G, Rykova MP, Konstantinova L. Immune changes in test animals during spaceflight. Journal of Leukocyte Biology, Sept 1993, 54:214-226.

Morton DS; Swiggett JP; Hakenewirth AM; Fowler NA; Sonnenfeld G : Effects of movement limitation on immunological parameters. American Society for Gravitational and Space Biology, Oct 1995, 9(1):32.

Sonnenfeld G. Animal models for the study of the effects of spaceflight on the immune system. Adv Space Res. 2003;32(8):1473-6

Sonnenfeld G; Davis S; Taylor GR; Mandel AD; Konstantinova IV; Lesnyak A; Fuchs BB; Peres C; Tkackzuk J; Schmidtt DA: Effect of space flight on cytokine production and other immunologic parameters of rhesus monkeys. Journal of Interferon Cytokine Research, May 1996, 16(5):409-415.

Sonnenfeld G; Davis S; Taylor GR; Mandel AD; Lesnyak A; Fuchs BB; Konstantinova IV: Cosmos 2229 Immunology study (Experiment K-8-07). Final Reports of the US Experiments Flown on the Soviet Biosatellite Cosmos 2229, Apr 1997.

Keywords
B-lymphocytes
Bone marrow
Bone marrow cells
Cell count
Granulocyte-macrophage colony-stimulating factor
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Response, immunologic, Anti-human IgM, surface markers, bone marrow cells, primate, Microscope, antibody stain
Response, immunologic, Anti-human IgM, surface markers, red blood cells, primate, Microscope, antibody stain
Response, immunologic, Anti-Monkey IgG F(ab)', surface markers, bone marrow cells, primate, Microscope, antibody stain
Response, immunologic, Anti-Monkey IgG F(ab)', surface markers, red blood cells, primate, Microscope, antibody stain
Response, immunologic, Anti-monkey IgG, surface markers, bone marrow cells, primate, Microscope, antibody stain
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2229 12/29/1992 01/10/1993 12 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
K-8-07
Protocol / Approach
Synchronous control
Vivarium control
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items