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EXPERIMENT INFORMATION

DEXA Measurements: Cosmos 2229 Rhesus Flight Experiment (COS 2229-5)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Macaca mulatta Species: Monkey Strain: Rhesus

Description
Objectives:

Previous spaceflights have documented that significant bone and muscle atrophy occurs during weightlessness. In addition to bone and muscle loss, renal stones may also form during flight. These effects may require that countermeasures be taken for their prevention. It is hypothesized that short duration weightlessness will decrease bone formation and increase bone resorption and that this will be apparent as a decrease in bone mineral immediately after flight or during the first few weeks following flight. Further, it is hypothesized that short duration weightlessness will result in significant muscle atrophy that will be rapidly recovered following return to 1-g. The objective of this experiment was to determine, using regional and whole body dual energy x-ray absorbtiometry (DEXA) , if bone and lean body mass are reduced in the Rhesus monkey after exposure to short duration weightlessness.


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Publications
LeBlanc A, Evans H, Shackelford L, West S. DEXA Measurements: Cosmos 2229 Rhesus Flight Experiment. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2229, Apr 1997.

Zerath E, Novikov V, LeBlanc A. Effects of spaceflight on bone mineralization in the rhesus monkey. Journal of Applied Physiology, July 1996, 81(1):194-200.

Keywords
Adipose tissue
Bone density
Bone remodeling
Densitometry, X-Ray
Disease models, animal
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Content, Fat, lower body, primate, Dual energy x-ray absorptiometry (DEXA)
Content, Fat, spinal region, primate, Dual energy x-ray absorptiometry (DEXA)
Content, Fat, tibial region, primate, Dual energy x-ray absorptiometry (DEXA)
Content, Fat, upper body, primate, Dual energy x-ray absorptiometry (DEXA)
Content, Fat, whole body, primate, Dual energy x-ray absorptiometry (DEXA)
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2229 12/29/1992 01/10/1993 12 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
K-8-01(3)
Protocol / Approach
Asynchronous control
Vivarium control
Proposal Date
6/17/1988
Proposal Source
88-OSSA-9
Hardware Items