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Plasma Hormone Concentration in Rhesus Monkeys After Space Flight (COS 2229-6)
Principal Investigator
Research Area:
Species Studied
Scientific Name: Macaca mulatta Species: Monkey Strain: Rhesus


Previous studies have shown changes in plasma concentrations of several hormones in humans and rats after spaceflight. Growth hormone (GH) levels after flight, as measured by immunoassay, have been increased (astronauts) or decreased (cosmonauts) in humans. Rats have shown no change or decreased GH. By bioassay, rats have shown marked suppression of GH concentrations. Testosterone levels in rats were invariably reduced. Thyroid hormones have been reported to be increased, decreased or unchanged in various flights. Calcitonin was reduced and parathyroid hormone increased in Cosmos 2044 rats. Adrenal steroid levels have typically been markedly elevated in both control and space flight rats after flight, with no significant differences between groups. To further understand the effects of spaceflight on endocrine function, the circulating levels of growth hormone, insulin-like growth factor I (IGF-I), thyroid hormones, cortisol and testosterone in young males rhesus monkeys were investigated following 12.5 days in space.

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Grindeland, RE, Mukku, VR, Gosselink, KL, Dotsenko, R: Plasma hormone concentrations in rhesus monkeys after spaceflight. Final Reports of the US Experiments Flown on the Soviet Biosatellite Cosmos 2229 , Apr 1997.

Insulin-like growth factor I
Thyroid hormones
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Content, Cortisol, plasma, blood, primate, Commercial radioimmunoassay (RIA)
Content, Growth hormone (GH), plasma, blood, primate, in vitro Bioassay
Content, Insulin-like growth factor-I (IGF-I), plasma, blood, primate, Recombinant human IGF-I (RAI)
Content, Testosterone, plasma, blood, primate, Commercial radioimmunoassay (RIA)
Content, Thyroxine (T4), plasma, blood, Primate, Commercial radioimmunoassay (RIA)
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 2229 12/29/1992 01/10/1993 12 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Asynchronous control
Vivarium control
Proposal Date
Proposal Source
Hardware Items