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Spaceflight Effects on Muscle Fibers (COS 936-3)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar


Whether a muscle fiber employs an oxidative or glycolytic energy mechanism is not immutably fixed, but can be influenced by external factors. Since space flight drastically alters the stimulus patterns to which skeletal muscle is exposed, it is relevant to investigate the changes which take place, not only in the muscle fiber size, but also in the energy mechanism. Rather than sampling each muscle only at a few positions along its length, this experiment seeks a quantitative total ascertainment of fiber size, number, and type.

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Castleman, K.R. and L.A. Chui: Spaceflight Effects on Muscle Fibers. Final Reports of U.S. Experiments Flown on the Soviet Satellite Cosmos 936. S.N. Rosenzweig and K.A. Souza, eds., NASA TM-78526, 1978, pp. 274-289.

Castleman, K.R. et al.: Quantitative Muscle Biopsy Analysis. Proceedings of the SPIE, vol. 89, 1976, p. 119.

Van Der Meulen, J.P. et al.: Computer Assisted Quantitative Analysis of Muscle Biopsy: Preliminary Observations. Neurology, vol. 274, 1977, p. 355.

Muscle, skeletal
Muscle fibers, fast-twitch
Muscle fibers, slow-twitch

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Area, cross section, Extensor digitorum longus, muscle, rat, Histology, microscopy
Area, cross section, Fiber, extensor digitorum longus (EDL), muscle, rat, Immunochemistry, microscopy
Properties, type, Fiber, extensor digitorum longus, muscle, rat, Histochemistry
Size, length, Extensor digitorum longus, muscle, rat, Gross measurement
Weight, tissue, Extensor digitorum longus, muscle, rat, Balance (CGS units)

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 936 08/03/1977 08/22/1977 19 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Protocol / Approach