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Effects of Spaceflight Stress on Pro-opiomelanocortin, Proenkephalin A and Tachykinin Neurpepetidergic Systems in the Rat Posterior Pituitary (PARE02 BSP2)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley


Stress is known to cause an increase in the secretion of beta endorphins and methionine enkephalins into the blood stream. Both of these substances have a sedative effect or inhibit stimulation. Substance P is also an important neuropeptide in the stress process due to its ability to normalize stress disorders. The objective of this study was to examine the levels of these peptides in response to the unique stresses of spaceflight.

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Zhu X, Desiderio DM: Effects of space flight stress on proopiomelanocortin, proenkephalin A, and tachykinin neuropeptidergic systems in the rat posterior pituitary. Life Sciences, vol. 55(5), 1994, pp. 347-350.

Enkephalin, methionine
Pituitary gland
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Content, Beta-endorphin-like immunoreactivity (BE-li), posterior pituitary. rat, Radioimmunoassay
Content, Methionine enkephalin-like immunoreactivity (ME-li), posterior pituitary. rat, Radioimmunoassay
Content, Protein, total, posterior pituitary, rat, Micro-colorimetry
Content, Substance P-like immunoreactivity (SP-li), posterior pituitary. rat, Radioimmunoassay
Weight, Whole body, Balance (CGS units)

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-54 01/13/1993 01/19/1993 6 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Asynchronous control
Proposal Date
Proposal Source
Dear Colleague Letter