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EXPERIMENT INFORMATION

Effect of Spaceflight on Oxidative and Antioxidant Enzyme Activity in Rat Diaphragm and Intercostal Muscles (PARE02 BSP5)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley

Description
Objectives:

Previous studies show oxidative marker enzymes respond to microgravity differently in different muscle fibers. In hindlimb suspension studies, oxidative enzyme levels have been shown to both increase and decrease in different experiments. The purpose of this experiment was to examine the effects of microgravity on oxidative and antioxidative enzyme levels in respiratory muscles.


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Publications
Lee MD, Tuttle R, Girten B: Effect of Spaceflight on Oxidative and Antioxidant Enzyme Activity in Rat Diaphragm and Intercostal Muscles. Journal of Gravitational Physiology, vol. 2 (1), 1995, pp. 68-69.

Keywords
Antioxidants
Citrate (si)-synthase
Diaphragm
Enzymes
Intercostal muscles
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Citrate synthase, diaphragm, muscle, rat, Spectrophotometric (enzyme units)
Activity, enzymic, Citrate synthase, intercostal, muscle, rat, Spectrophotometric, (enzyme units)
Activity, enzymic, Lipid peroxidation, diaphragm, muscle, rat, Malondialdehyde, 4-hydroxyalkenal (by-products of lipid peroxidation)
Activity, enzymic, Lipid peroxidation, intercostal , muscle, rat, Malondialdehyde, 4-hydroxyalkenal (by-products of lipid peroxidation)
Activity, enzymic, Superoxide dismutase, diaphragm, muscle, rat, Spectrophotometric (enzyme units)
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-54 01/13/1993 01/19/1993 6 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Asynchronous control
Proposal Date
11/5/1992
Proposal Source
Dear Colleague Letter