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EXPERIMENT INFORMATION

The Effects of Spaceflight on Some Liver Enzymes Concerned with Carbohydrate and Lipid Metabolism in the Rat (COS 936-2)
Principal Investigator
Research Area:
Metabolism and nutrition
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

During early manned space flights, a specific physiological enigma concerning caloric requirements was noted. While theoretically in the absence of gravitational force less energy should be required for life-sustaining functions, on the initial flights where caloric intake was restricted, a marked inflight loss in body weight resulted. It is important to study a key organ like the liver in order to determine whether any regulative enzymes of carbohydrate and lipid metabolism might have been affected; that is, whether the capabilities of the organ to produce these cellular constituents is, in fact, altered in space flight.


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Publications
Abraham, S. et al.: The Effects of Spaceflight on Some Liver Enzymes Concerned with Carbohydrate and Lipid Metabolism in Rats. Physiologist, vol. 21, no. 4, 1978.

Abraham, S. et al.: The Effects of Spaceflight on Some Liver Enzymes Concerned with Carbohydrate and Lipid Metabolism in the Rat. Final Reports of U.S. Experiments Flown on the Soviet Satellite Cosmos 936. S.N. Rosenzweig and K.A. Souza, eds., NASA TM-78526, 1978, pp. 78-134.

Abraham, S. et al.: The Effects of Spaceflight on Some Rat Liver Regulating Carbohydrates and Lipid Metabolism. Advances in Space Research, vol. 1, no. 14, 1981, pp. 199-217.

Keywords
Aconitate hydratase
Acyltransferases
Carbohydrates
Cytosol
Fatty acids
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Carbohydrate, lipid metabolism, liver, rat, Assay
Content, Cholesterol, liver, rat, Clinical analysis
Content, Cytochrome-c, liver, rat, Clinical analysis
Content, Glycogen, liver, rat, Clinical analysis
Content, Lipid peroxidation (dienic conjugates, malonic dialdehyde, Schiff's bases, tocopherol): liver, Rat, Biochemical analyses
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 936 08/03/1977 08/22/1977 19 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C936-2
Protocol / Approach