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EXPERIMENT INFORMATION

Osteoblast Adhesion and Phenotype in Microgravity (9304022 1_2)
Principal Investigator
Research Area:
Skeletal physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: ROS cell line

Description
Objectives:

The purpose of this experiment was to investigate: 1) whether microgravity induces changes in osteoblastic cells similar to those caused by bone resorption-stimulating agents like parathyroid hormone (PTH), and 2) whether those phenotypic changes are associated with alterations in cell shape and/or adhesive interactions with the extracellular matrix.


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Keywords
Osteoblasts
Parathyroid hormones
Cytoskeleton

Data Information
Data Availability
Archive is complete. All data sets are on the Web site.
Data Sets + View data.

Parameters
Activity, cell, Osteoblast, osteosarcoma, Cell culture, Observational
Activity, enzymic, Alkaline phosphatase (AP), growth media, osteosarcoma cell culture, rat, Assay
Activity, metabolism, bone cell culture, rat, Assay
Cell reactions with substrata
Cell viability
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-69 09/07/1995 09/18/1995 11 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Synchronous control
Proposal Date
9/1/1993
Proposal Source
93-OLMSA-04