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Effects of Spaceflight on the Development of the Circadian Timing System (9303024)
Principal Investigator
Research Area:
Developmental biology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley


The objectives of this experiment were to determine the effect of spaceflight on: retinal development; development of the suprachiasmatic nucleus (SCN), the circadian pacemaker of the circadian timing system (CTS); maturation of the retino-hypothalamic tract (RHT); and the development and maturation of circadian rhythms.

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Hoban-Higgins TM, Murakami DM, Fermin C, Fuller CA: Development of circadian rhythms of body temperature and activity in Sprague-Dawley rat pups. Society for Neuroscience, vol. 21, 1995, pp. 955.

Murakami DM, Tang IH, Hoban-Higgins TM, Fuller CA: The development of the photic induction of c-Fos in the retina and SCN. Society for Neuroscience, vol. 21, 1995, pp. 956.

Murakami DM, Tang IH, Hoban-Higgins TM, Fuller CA: The effect of spaceflight on retino-hypothalamic development. Journal of Gravitational Physiology, vol. 4, 1997, pp. 67.

Circadian rhythm
Proto-oncogene proteins
Suprachiasmatic nucleus

Data Information
Data Availability
Archiving in Progress. Some data exist for this experiment.
Data Sets+ View data

NASA GeneLab Data

Activity, circadian rhythm, Rat, Microgravity
Circadian rhythm amplitude
Circadian rhythm onset
Inner nuclear development: retina
Inner plexiform development: retina
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-70 07/13/1995 07/22/1995 9 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Delayed synchronous control
Vivarium control
Proposal Date
Proposal Source