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Role of Corticosteroids in Bone Loss During Space Flight (284071)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Sprague-Dawley


Previous studies have shown that stress-induced corticosteroid hormones increase during spaceflight. Negative effects on bone, such as decreased bone formation, are also associated with these hormones. The objective of this study was to determine whether corticosteroid excesses contribute to the bone loss that occur during spaceflight.

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Howe EE, Wronski TJ, Halloran BP, Miller SC. Histologic changes in the adrenal cortex from young rats following spaceflight. Aviat Space Environ Med. 2000 Oct;71(10):1039-44.

Vajda EG, Wronski TJ, Halloran BP, Bachus KN, Miller SC. Spaceflight alters bone mechanics and modeling drifts in growing rats. Aviat Space Environ Med. 2001 Aug;72(8):720-6.

Wronski TJ, Halloran BP, Miller SC. Role of corticosteroids in bone loss during space flight. In: Life and Microgravity Spacelab (LMS): Final Report. 1998. J.P. Downey (ed.), NASA/CP-1998-206960, 338-360.

Wronski TJ, Li M, Shen Y, Miller SC, Bowman BM, Kostenuik P, Halloran BP. Lack of effect of spaceflight on bone mass and bone formation in group-housed rats. J. Appl. Physiol. 1998, 85:279-285.

Area, Bone, tibia, rat, Microscopy
Area, Marrow, tibia, bone, rat, Microscopy
Bone width: right tibia
Osteoblast surface: left tibia
Osteoclast surface: left tibia
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-78 06/20/1996 07/07/1996 17 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Delayed synchronous control
Vivarium control
Proposal Date
Proposal Source