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EXPERIMENT INFORMATION

Studies of Specific Hepatic Enzymes and Liver Constituents Involved in the Conversion of Carbohydrates to Lipids in Rats Exposed to Prolonged Spaceflight (COS 1129-5)
Principal Investigator
Research Area:
Metabolism and nutrition
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Examination of liver, blood, muscle, and skeletal tissues from rats aboard earlier Cosmos flights indicated changes in the lipid and carbohydrate levels of these tissues in response to space flight. These metabolic alterations, both in enzyme levels and in hepatic constituents, appeared to be unique to the weightless condition. The present study was designed to reinvestigate some of these earlier observations and to extend the range of inquiry to include additional hepatic microsomal and mitochondrial enzymes, as well as other liver constituents (total lipids, triglycerides, phospholipids, and sterols) not included in the original Cosmos 936 protocol.


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Publications
Abraham, S. et al.: Biochemical Changes in Rat Liver After 18.5 Days of Spaceflight. Proceedings of the Society for Experimental Biology and Medicine, vol. 172, 1983, pp. 334-339.

Abraham, S. et al.: Studies of Specific Hepatic Enzymes and Liver Constituents Involved in the Conversion of Carbohydrates to Lipids in Rats Exposed to Prolonged Spaceflight Aboard Cosmos 1129. Physiologist, supl., vol. 23, 1980, pp. S55-S58.

Abraham, S. et al.: Studies of Specific Hepatic Enzymes and Liver Constituents Involved in the Conversion of Carbohydrates to Lipids in Rats Exposed to Prolonged Spaceflight. Final Reports of U.S. Rat Experiments Flown on the Soviet Satellite Cosmos 1129. M.R. Heinrich and K.A. Souza, eds., NASA TM-81289, 1981, pp. 35-100.

Abraham, S. et al.: The Effects of Spaceflight on Some Rat Liver Enzymes Regulating Carbohydrates and Lipid Metabolism. Advances in Space Research, vol. 1, no. 14, 1981, pp. 199-217.

Keywords
Acyltransferases
Carbohydrates
Cholesterol
Cholesterol esters
Cytochrome c
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Carbohydrate, lipid metabolism, liver, rat, Assay
Content, Cholesterol, liver, rat, Clinical analysis
Content, Cytochrome-c, liver, rat, Clinical analysis
Content, Glycogen, liver, rat, Clinical analysis
Content, Lipid peroxidation (dienic conjugates, malonic dialdehyde, Schiff's bases, tocopherol): liver, Rat, Biochemical analyses
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1129 09/25/1979 10/14/1979 19 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1129-11
Protocol / Approach
Hardware Items