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CNS Control of Rhythms and Homeostasis During Space Flight (9301132)
Principal Investigator
Research Area:
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Fischer 344


Research has shown that the static gravitational field of the Earth and the dynamic cyclic changes caused by the Earth�s rotation are two important selective pressures that shaped the evolution of biological organisms. Many features of an animal�s physiology and behavior are a consequence of both static and dynamic geophysical influences. The circadian timing system (CTS) is one important temporal organizer controlling both physiology and behavior. Animals (including humans) exposed to microgravity exhibit alterations in both CTS function and homeostasis. These experiments examined the effects of space flight on the physiology of the CTS and the homeostatic control system of animals, specifically: 1) circadian rhythms; 2) neural responses of the circadian pacemaker and the sensory pathway for light information from the retina to the CTS; 3) adaptations in homeostatic regulation; and 4) neural changes in hypothalamic nuclei that regulate specific homeostatic functions.

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Fuller, C. A. et al.: The Effects of Spaceflight on the Rat Circadian Timing System. In: The Neurolab Spacelab Mission: Neuroscience Research in Space, ed. J.C. Buckey and J.L. Homick, NASA SP-2003-535, 2003, pp. 233-241.

Homick JL, Delaney P, Rodda K. Overview of the Neurolab Spacelab mission. Acta Astronaut. 1998 Jan-Apr;42(1-8):69-87

Circadian rhythm
Proto-oncogene proteins
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Data Information
Data Availability
Archive is complete. All data sets are on the Web site.
Data Sets + View data.

Activity, circadian rhythm, Rat, primate, Microgravity
Activity, Heart rate, rat, Implanted EKG electrodes, downlink telemetry
Activity, Heart rate, rat, Implanted transmitter, continuous EKG, rate algorithm
Consumption, Diet, rat, primate, Measured food
Consumption, Diet, rat, primate, Measured water
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
STS-90 04/17/1998 05/03/1998 16 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Protocol / Approach
Delayed synchronous control
Vivarium control
Simulated flight control
Proposal Date
Proposal Source