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EXPERIMENT INFORMATION

Quantitative Analysis of Selected Bone Parameters: Supplemental Report 1: Effects of Weightlessness on Osteoblast (COS 1129-15)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Marked depression or arrest of bone formation has been associated with space flight and simulated weightlessness. The mechanism of this suppression of osteogenesis is unclear, but probably involves altered induction. Data indicate that nuclear volume frequency distributions are an effective means of assaying preosteoblast differentiation in a population of connective tissue cells. Thus, the objective of this experiment was to determine whether space flight would alter cellular induction in the fibroblast-like cells in the rat periodontal ligament (PDL).


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Publications
Roberts, W.E. and P.G. Mozsary: Effects of Weightlessness on Osteoblast Differentiation in Rat Molar Periodontium. Proceedings of the Aerospace Medical Association Meeting, San Antonio, Tex., May 3-6, 1981, pp. 114-115.

Roberts, W.E. et al.: Nuclear Volume Assay of Osteogenic Potential in Ulna Primary Spongiosa of Rats Flown in Space for 18.5 Days. Anatomical Record, vol. 214, 1986, p. 109A.

Roberts, W.E. et al.: Quantitative Analysis of Selected Bone Parameters: Supplemental Report 1: Effects of Weightlessness on Osteoblast. Final Reports of U.S. Rat Experiments Flown on the Soviet Satellite Cosmos 1129. M.R. Heinrich and K.A. Souza, eds., NASA TM-81289, 1981, pp. 127-148.

Roberts, W.E. et al.: Suppression of Osteoblast Differentiation During Weightlessness. Physiologist, supl., vol. 24, 1981, pp. S75-S76.

Keywords
Bone and bones
Bone mineralization
Cell count
Cell physiology
Fibroblasts
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Count, Osteoblast, periodontal ligament (PDL), rat, Histology, microscopy
Count, Osteoprogenitors, periodontal ligament (PDL), rat, Histology, microscopy
Count, Precursor cells, periodontal ligament (PDL), rat, Histology, microscopy
Count, Preosteoblasts, periodontal ligament (PDL), rat, Histology, microscopy
Formation, Bone, maxillea, rat, Morphometry
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1129 09/25/1979 10/14/1979 19 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1129-3.2
Protocol / Approach
Hardware Items