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EXPERIMENT INFORMATION

Quantitative Analysis of Selected Bone Parameters: Bone Elongation Rate and Bone Mass in Metaphysis of Long Bones (COS 1129-16)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

The purpose of this study was to determine whether bone elongation rate and bone cell number in the metaphysis of long bones were altered by Cosmos 1129 space flight. An attempt was made to measure the rate of bone elongation directly in the proximal tibial and humeral metaphysis by the use of tetracycline labeling.


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Publications
Jee, W.S.S. et al.: Effects of Spaceflight on Trabecular Bone in Rats. American Journal of Physiology, vol. 244, 1983, pp. R310-R314.

Jee, W.S.S. et al.: Quantitative Analysis of Selected Bone Parameters: Supplement 2: Bone Elongation Rate and Bone Mass in Metaphysis of Long Bones. Final Reports of U.S. Rat Experiments Flown on the Soviet Satellite Cosmos 1129. M.R. Heinrich and K.A. Souza, eds., NASA TM-81289, 1981, pp. 149-175.

Kimmel, D.B. and W.S.S. Jee: A Quantitative Histologic Analysis of the Growing Long Bone Metaphysis. Calcified Tissue International, vol. 32, 1980, pp. 113-122.

Keywords
Bone and bones
Bone marrow
Bone mineralization
Calcification, physiologic
Cartilage
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Area, Marrow, humerus, bone, rat, Microscopy
Area, Marrow, tibia, bone, rat, Microscopy
Count, Osteoblast, humerus, bone, rat, Histology, microscopy
Count, Osteoprogenitors, humerus, bone, rat, Histology, microscopy
Formation, bone, Humerus, cartilage, tetracycline labeling, fractional calcified cartilage volumes, Calculation
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1129 09/25/1979 10/14/1979 19 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1129-3.3
Protocol / Approach
Hardware Items