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EXPERIMENT INFORMATION

Automatic Analysis of Muscle Fibers from Rats Subjected to Spaceflight (COS 1129-7)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Space flight and microgravity are known to produce systemic and metabolic changes in animals and humans. Even though the effects of weightlessness in various organ systems are well described, the pathophysiological mechanism is largely unknown. In this experiment, muscle size and fiber type distribution were studied in the plantaris and gastrocnemius muscles.


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Publications
Castleman, K.R. et al.: Automatic Analysis of Muscle Fibers From Rats Subjected to Spaceflight. Final Reports of U.S. Rat Experiments Flown on the Soviet Satellite Cosmos 1129. M.R. Heinrich and K.A. Souza, eds., NASA TM-81289, 1981, pp. 267-278.

Chui, L.A. and K.R. Castleman: Morphometric Analysis of Rat Muscle Fibers Following Spaceflight and Hypogravity. Physiologist, supl., vol. 23, 1980, pp. S76-S78.

Keywords
Cross-sectional area (CSA)
Muscle fibers
Muscle fibers, fast-twitch
Muscle fibers, slow-twitch
Muscle, skeletal
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Area, cross section, Fiber, gastrocnemius, muscle, rat, Immunochemistry, microscopy
Area, cross section, Fiber, plantaris, muscle, rat, Immunochemistry, microscopy
Area, cross section, Gastrocnemius, muscle, rat, Histology, microscopy, image analysis
Area, cross section, Plantaris, muscle, rat, Histology, microscopy
Area, Fiber, dark, gastrocnemius, muscle, rat, Microscopy, image analysis
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1129 09/25/1979 10/14/1979 19 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Sylvain Costes
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1129-5
Protocol / Approach
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