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EXPERIMENT INFORMATION

The Effect of Spaceflight on Osteogenesis and Dentinogenesis in the Mandibles of Rats (COS 1129-18)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Efforts to understand how prolonged space flight effects changes in calcium homeostasis and bone formation-resorption have been pursued on past Cosmos missions. This study examines the effect of space flight on the integrated growth and remodeling of a non-weight bearing bone, the mandible and teeth, to determine how microgravity affects tissues in a skeletal element which is only supplied with a large antigravity muscle (masseter).


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Publications
Rosenberg, G.D. and D.J. Simmons: Time Varying Calcium, Phosphorus and Sulfur Concentrations in Rat Incisors: Three Effects of Spaceflight (Cosmos 1129 Biosatellite). The Chemistry and Biology of Mineralized Connective Tissue, A. Veis, ed., Elsevier North Holland, Inc., 1981, pp. 295-297.

Simmons, D.J. and G.D. Rosenberg: The Effects of Spaceflight on the Mineralization of Rat Incisor Dentin. Proceedings of the Society for Experimental Biology and Medicine, vol. 175, 1984, pp. 429-437.

Simmons, D.J. et al.: Bone Growth in the Rat Mandible During Spaceflight. Physiologist, supl., vol. 23, 1980, pp. S87-S90.

Simmons, D.J. et al.: Effect of Spaceflight on the Non-Weightbearing Bones of Rat Skeleton. American Journal of Physiology, vol. 244, 1983, pp. R319-R326.

Simmons, D.J. et al.: The Effect of Spaceflight on Osteogenesis and Dentinogenesis in the Mandibles of Rats. Final Reports of U.S. Rat Experiments Flown on the Soviet Satellite Cosmos 1129. M.R. Heinrich and K.A. Souza, eds., NASA TM-81289, 1981, pp. 279-306.

Simmons, D.J.: Adaptation of the Rat Skeleton to Weightlessness and Its Physiological Mechanisms. Physiologist, supl., vol. 24, 1981, pp. S65-S68.

Keywords
Bone and bones
Bone matrix
Bone mineralization
Bone remodeling
Calcium
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Content, Calcium, mandible, bone, rat, Microprobe, crystal sensors
Content, Collagen, mandible, bone, rat
Content, Hydroxyproline, mandible, bone, rat
Content, Phosphorus, mandible, bone, rat, Microprobe, crystal sensors
Content, Sulfur, mandible, bone, rat, Microprobe, crystal sensors
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1129 09/25/1979 10/14/1979 19 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1129-6.1
Protocol / Approach
Hardware Items