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Analysis of a Clinical Database as a Means to Validate Non-invasive Assessment of Intracranial Pressure Using the Cerebral and Cochlear Fluid Pressure (CCFP) Analyzer (CCFP_Analyzer)
Principal Investigator
Research Area:
Biomedical countermeasures
Species Studied
Scientific Name: Homo sapiens Species: Human

Visual impairment intracranial pressure (VIIP) is a top risk for human space flight, yet there are no reliable means to monitor intracranial pressure (ICP) non-invasively, particularly in flight. A lumbar puncture (LP) is invasive and isn’t a viable option for in flight monitoring, and are only used on crewmembers exhibiting significant VIIP symptoms. Development and validation of a noninvasive means of monitoring ICP would result in collection of data that could define the involvement of elevated ICP in the VIIP syndrome. The Cochlear and Cerebral Fluid Pressure (CCFP) analyzer measures tympanic membrane displacement (TMD) in both evoked and passive modes. These TMD waveforms change in response to ICP alterations, allowing a noninvasive means to monitor ICP changes. Additional clinical validation of the CCFP analyzer is necessary to better understand the device’s utility. The Ear and Balance Institute has over 1,000 patient records of CCFP tests, many with accompanying LP measures. Analysis of the results of these tests has helped validate the use of the CCFP technology as a surrogate measure of ICP. The purpose of this retrospective clinical study was to examine this unique CCFP and LP data set, in order to identify characteristics that could contribute to follow-on studies employing the CCFP analyzer.

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Tympanic membrane
Intracranial pressure

Data Information
Data Availability
Archive is complete. Data sets are not publicly available but can be requested.
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Cerebrospinal fluid (CSF)
Intracranial pressure (ICP)
Lumbar puncture (LP)
Tympanic membrane displacement (TMD)

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Ground 05/01/2009 In Progress

Human Research Program (HRP) Human Research Roadmap (HRR) Information
Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) investigates and mitigates the highest risks to human health and performance, providing essential countermeasures and technologies for human space exploration. Risks include physiological and performance effects from hazards such as radiation, altered gravity, and hostile environments, as well as unique challenges in medical support, human factors, and behavioral health support. The HRP utilizes an Integrated Research Plan (IRP) to identify the approach and research activities planned to address these risks, which are assigned to specific Elements within the program. The Human Research Roadmap is the web-based tool for communicating the IRP content.

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Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Terry Hill
Institutional Support
National Aeronautics and Space Administration (NASA)
Proposal Date
Proposal Source
Directed Research