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EXPERIMENT INFORMATION

Structural and Metabolic Plasticity of Leg Muscle (B11-03)
Research Area:
Muscle physiology
Species Studied
Scientific Name: Macaca mulatta Species: Monkey Strain: Rhesus

Description
Objectives:

Changes in the structure and metabolism of the skeletal muscles of the leg have been observed in both humans and animals after space flight. Some examples of the effects of microgravity on skeletal muscle are changes in the cross-sectional area of slow- and fast-twitch muscle fibers, decreases in fiber size (muscle atrophy), and decreases in oxidative potential and number of capillaries. Although most investigators believe that the major factor affecting these changes in the extensor muscles is the gravitational unloading experienced in space, others believe that factors such as physical exercise or dehydration may also have an impact. Rhesus monkeys can be used effectively in studies of the musculoskeletal system in microgravity, as their physiology is similar to humans, and monkey experiments can be performed under controlled conditions to exclude the masking effect of countermeasures used by human subjects. This experiment examined the effect of microgravity and diminished motor activity (restraint) on the structure and metabolism of the m. vastus lateralis and m. soleus muscles of the Rhesus monkey.


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Publications
Belozerova, I.N. et al.: Structural and Metabolic Profile of Rhesus Monkey m. vastus lateralis after Spaceflight. Journal of Gravitational Physiology, vol. 7(1), Jan 2000, pp. S55-S58.

Mazin, M.G. et al.: Ultrastructure of Skeletal Muscles of Rhesus Monkeys after Spaceflight. Journal of Gravitational Physiology, vol. 7(1), Jan 2000, pp. S59-S62.

Shenkman, B.S. et al.: Structural and Metabolic Characteristics of Rhesus Monkey m. soleus after Spaceflight. Journal of Gravitational Physiology, vol. 7(1), Jan 2000, pp. S39-S42.

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Activity, enzymic, Cytochrome-C oxidase, vastus lateralis, muscle, primate, Assay (OD units)
Activity, enzymic, Glucose-6-phosphate dehydrogenase (GDP), vastus lateralis, soleus, muscle, primate, Assay (enzyme units)
Activity, enzymic, Glutamate dehydrogenase, vastus lateralis, soleus, muscle, primate, Assay (enzyme units)
Activity, enzymic, Succinate dehydrogenase (SDH), vastus lateralis, soleus, muscle, primate, Assay (enzyme units)
Area, cross section, Fiber, soleus, muscle, primate, Immunochemistry, microscopy
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Bion 11 12/24/1996 01/07/1997 13.5 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
B11-3
Protocol / Approach
Proposal Date
6/24/1988
Proposal Source
88-OSSA-8
Hardware Items