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Bone Tissue and Cell Effects of Spaceflight in Young Rhesus Monkey (B11-17)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Macaca mulatta Species: Monkey Strain: Rhesus


Previous space flight experiments utilizing the rat have shown that bone loss during microgravity exposure is primarily due to diminished bone formation. Few histological studies have been done on non-human primates flown in space, and delays between reentry and surgery in those experiments prevented early post-flight cell activity studies. This experiment was the first to investigate bone cell activities in space-flown primates using histological and cell culture methods.

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Zerath E, Grynpas M, Holy X, Viso M, Patterson-Buckendahl P, Marie PJ. Spaceflight affects bone formation in rhesus monkeys: a histological and cell culture study. J Appl Physiol. 2002 Sep;93(3):1047-56.

Zerath, E. et al.: Effects of Bion 11 14-day Space Flight on Monkey Iliac Bone. Journal of Gravitational Physiology, vol. 7(1), Jan 2000, pp. S155-156.

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Activity, function, Osteoblast cell, iliac crest, bone, primate, Electron microscopy (observational, classification)
Area, Mineral surface, Iliac crest, primate, Histology, microscopy
Area, surface, osteoblasts, iliac, bone, monkey, Histomorphometry
Area, surface, osteoclasts, iliac, bone, monkey, Histomorphometry
Bone formation
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Bion 11 12/24/1996 01/07/1997 13.5 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Proposal Date
Proposal Source
Hardware Items