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EXPERIMENT INFORMATION

The Effect of Spaceflight on Osteogenesis and Dentinogenesis in the Mandible of Rats: Supplement 1: The Effects of Spaceflight on Alveolar Bone Remodeling in the Rat Mandible (COS 1129-19)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Under space flight conditions, and assuming animals are eating normally, alveolar bone should be subjected to only slightly different mechanical conditions, which should not induce marked changes in bone remodeling if all other metabolic conditions are unchanged. On the other hand, if the changes observed in the long bone are due totally or in part to systemic changes, alveolar bone remodeling should also be affected, and even more markedly considering its high normal turnover rate.


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Publications
Simmons, D.J. et al.: Bone Growth in the Rat Mandible During Spaceflight. Physiologist, supl., vol. 23, 1980,
pp. S87-S90.

Simmons, D.J. et al.: Effect of Spaceflight on the Non-Weightbearing Bones of Rat Skeleton. American Journal of Physiology, vol. 244, 1983, pp. R319-R326.

Simmons, D.J.: Adaptation of the Rat Skeleton to Weightlessness and Its Physiological Mechanisms. Physiologist, supl., vol. 24, 1981, pp. S65-S68.

Tran Van, P. and M. Mailland: Early Response of Periodontal Ligament and Alveolar Bone to Hypofunction in the Rat. Journal of Dental Research, vol. 38, Special Issue D, 1979, p. 2261.

Tran Van, P. et al.: The Effect of Spaceflight on Osteogenesis and Dentinogenesis in the Mandible of Rats: Supplement 1: The Effects of Spaceflight on Alveolar Bone Remodeling in the Rat Mandible. Final Reports of U.S. Rat Experiments Flown on the Soviet Satellite Cosmos 1129. M.R. Heinrich and K.A. Souza, eds., NASA TM-81289, 1981, pp. 307-324.

Keywords
Bone and bones
Bone mineralization
Bone remodeling
Calcification, physiologic
Calcium
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Area, Bone, molar, rat, Histomorphometry
Bone formation: osteoid tissue, molar
Bone mineralization: molar
Content, Calcium, mandible, bone, rat, Dynamic histomorphometry
Content, Calcium, mandible, bone, rat, Microprobe, crystal sensors
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1129 09/25/1979 10/14/1979 19 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1129-6.2
Protocol / Approach
Hardware Items