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Complex Study of Micro and Macro Structure and Mineral Composition of Spongy Bone (B11-30)
Principal Investigator
Research Area:
Bone and calcium physiology
Species Studied
Scientific Name: Macaca mulatta Species: Monkey Strain: Rhesus


Exposure to microgravity leads to many changes in bone formation and growth. Diminished osteoblast production, osteoporotic signs, bone mass density loss, and reduced strength can occur. Though these effects can prove especially dangerous on long-term missions, little is known about the actual mechanisms by which bone loss occurs. The differentiation of osteoblasts and alteration of bone matrix in microgravity is not well understood. This study utilizes electron microscopy to examine bone changes in Bion 11 monkeys exposed to microgravity.

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Rodionova NV, Oganov VS, Zolotova NV. Ultrastructural changes in osteocytes in microgravity conditions. Adv Space Res. 2002; 30(4):765-70.

Rodionova, N.V. and V.S. Oganov: Morpho-functional Adaptations in the Bone Tissue Under the Space Flight Conditions. Journal of Gravitational Physiology, vol. 8(1), Jul 2001, pp. P87-88.

Rodionova, N.V. et al.: Bone Ultrastructural Changes in Bion 11 Rhesus Monkeys. Journal of Gravitational Physiology, vol. 7(1), Jan 2000, pp. S157-161.

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Activity, function, Osteoblast cell, iliac crest, bone, primate, Electron microscopy (observational, classification)
Activity, function, Osteocyte cell, iliac crest, bone, primate, Electron microscopy (observational, classification)
Cell ultrastructure: osteoblasts
Cell ultrastructure: osteocytes
Distribution, Osteoblasts, illiac crest, bone, primate, Electron microscopy (type, distribution, descriptive)
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Bion 11 12/24/1996 01/07/1997 13.5 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Protocol / Approach
Proposal Date
Proposal Source
Hardware Items