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Morphological and Functional Adaptations of Muscle Fibers Myo-tendonous Junction to Hypokinesia and Hypogravity (CNES F-07 1_2)
Principal Investigator
Research Area:
Muscle physiology
Species Studied
Scientific Name: Macaca mulatta Species: Monkey Strain: Rhesus


Previous studies have shown that both space flight and simulated microgravity (hind limb suspension) induce ultrastructural changes in the myotendinous junction (MTJ) of the soleus in the rat. The MTJ is a specialized region of skeletal muscle fibers where the muscle-tendon interface is increased by folding of the muscle fiber plasma membrane. The increased surface area results in reduced stress to the plasma membrane during contraction. A chronic change in muscle use and/or loading leads to a structural remodeling of the MTJ. Previously, only one histological study has examined the muscle-tendon interface in non-human primates. This experiment will examine the effects of space flight on the soleus MTJ ultrastructure in the rhesus.

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Carnino, A. et al.: Effects of a 14-day Spaceflight on soleus myotendinous Junction Ultrastructure in the Rhesus Monkey. Journal of Gravitational Physiology, vol 7(1), Jan 2000, pp. S65-S68.

Chopard, A. et al.: Effects of 14-day Spaceflight on Myosin Heavy Chain Expression in Biceps and Triceps Muscles of the Rhesus Monkey. Journal of Gravitational Physiology, vol 7(1), Jan 2000, pp. S47-S49.

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Morphology, Myotendinous junction, ultrastructure, soleus, muscle, rat, Micrography

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Bion 11 12/24/1996 01/07/1997 13.5 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Martha Del Alto
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
Protocol / Approach
Proposal Date
Proposal Source
Hardware Items