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EXPERIMENT INFORMATION

Bone Resorption in Rats During Spaceflight (COS 1129-11)
Principal Investigator
Research Area:
Bone and calcium physiology
Renal, fluid and electrolyte physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Calcium metabolism is altered in weightlessness. In humans, bone loss occurs and urinary calcium output is increased. Experiments on previous Cosmos flights have shown that bone formation in the tibia is depressed in young, growing rats, but no direct information has been obtained about bone resorption, or any of the other calcium metabolic parameters such as excretion, absorption, or net calcium balance. The basis of the present study was to determine the response of calcium homeostasis and bone to weightlessness.


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Publications
Cann, C.E. and R.R. Adachi: Bone Resorption and Mineral Excretion in Rats During Spaceflight. American Journal of Physiology, vol. 244, 1983, pp. R327-R331.

Cann, C.E. and R.R. Adachi: Bone Resorption in Rats During Spaceflight. Final Reports of U.S. Rat Experiments Flown Aboard the Soviet Biosatellite Cosmos 1129. M.R. Heinrich and K.A. Souza, eds., NASA TM-81289, 1981, pp. 427-438.

Cann, C.E. et al.: Bone Resorption and Calcium Absorption in Rats During Spaceflight. Physiologist, supl., vol. 23, 1980, pp. S83-S86.

Keywords
Bone and bones
Bone mineralization
Calcium
Magnesium
Minerals
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Composition, Diet, rat, Cosmos
Content, Calcium, in feces, rat, Atomic absorption spectrophotometry, isotope dilution
Content, Magnesium, in feces, rat, Atomic absorption spectrophotometry
Content, Mineral, in feces, rat, Atomic absorption spectrophotometry
Content, Phosphorus, in feces, rat, Atomic absorption spectrophotometry
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1129 09/25/1979 10/14/1979 19 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1129-7
Protocol / Approach
Hardware Items