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EXPERIMENT INFORMATION

Developmental Morphology of the Eye, Vestibular System, and Brain in 18-Day Fetal and Newborn Rats Exposed In Utero to Null Gravity During the Flight of Cosmos 1514 (COS 1514-1)
Principal Investigator
Research Area:
Developmental biology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

If it is assumed that female mammals demonstrate adaptive physiological responses to null-gravity exposure similar to flown males, then questions of transplacental expression of a variety of systemic effects from null-gravity exposure become highly significant in evaluating the results of developmental studies under altered gravity. Such an initial study of both direct and potentially indirect transplacental impacts of null-gravity on neural structures during the relatively stable midlife period represents the main thrust of this experiment.


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Publications
Keefe, J.R. et al.: Developmental Morphology of the Eye, Vestibular System, and Brain in 18-Day Fetal and Newborn Rats Exposed In Utero to Null Gravity During the Flight of Cosmos 1514. Final Reports of U.S. Monkey and Rat Experiments Flown on the Soviet Satellite Cosmos 1514. R.C. Mains and E.W. Gomersall, eds., NASA TM-88223, 1986, pp. 189-279.

Keefe, J.R. et al.: Effects of Fetal Period Null-Gravity Exposure on Wistar Rats During the Flight of Cosmos 1514. Physiologist, vol. 28, 1981, p. 262.

Keywords
Brain
Cell division
Cerebral cortex
Eye
Fetal development
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Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Damage, Developmental abnormalities, rat, Microscopy
Growth, rate, Rat, Measurement
Morphology, Brain ultrastructure, cerebral cortex, rat, Electron microscope
Morphology, Cell, choroid plexus, eye, rat, Microscopy (descriptive)
Morphology, Cytokinesis, brain, rat, Electron microscope
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1514 12/14/1983 12/19/1983 5 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1514-3
Protocol / Approach
Hardware Items