From previous bed-rest and flight studies with rodents, it is known that countermeasures such as exercise, lower-body negative pressure and muscle vibrations influence muscle atrophy and can restore NOS/NO signaling and the level of Homer proteins at the neuromuscular junction. Thus, both can function as biomarker for testing the efficiency of countermeasure protocols to maintain human skeletal muscle during space flight.
It is proposed to collect muscle tissue samples from astronauts flying to the International Space Station before and after their mission, and do a full analysis of the tissue on both the morphological/mechanical as well as on the molecular/biochemical level.
This is an international experiment. NASA does not currently have an agreement with international space partners to archive their data in the LSDA.
|Mission||Launch/Start Date||Landing/End Date||Duration|
|Expedition 46||12/11/2015||03/02/2016||82 days|
|Expedition 47||03/02/2016||06/18/2016||108 days|
|Expedition 48||06/18/2016||09/06/2016||80 days|
|Expedition 49||09/06/2016||10/30/2016||54 days|
|Expedition 50||10/28/2016||04/09/2017||164 days|
|Expedition 51||04/09/2017||06/02/2017||55 days|
|Expedition 52||06/02/2017||09/02/2017||92 days|
|Expedition 53||09/02/2017||12/14/2017||102 days|
|Expedition 54||12/14/2017||02/27/2018||75 days|
|Expedition 58||12/18/2018||03/14/2019||85 days|
|Expedition 59||03/14/2019||06/24/2019||102 days|
|Expedition 60||06/24/2019||10/03/2019||101 days|