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Structured Exercise Training as Countermeasure to Space Flight-Induced Orthostatic Intolerance (Ortho_Tolerance)
Principal Investigator
Research Area:
Cardiovascular physiology
Exercise physiology
Species Studied
Scientific Name: Homo sapiens Species: Human

Along with their scheduled on-orbit training program, the subjects perform a structured, individually-tailored, treadmill exercise training program. This program is planned by the PI on the basis of a pre-flight incremental treadmill exercise test, using the TRIMPi (individualized Training IMPulse) training methodology. The experiment requires the execution of a pre- and post-flight orthostatic tolerance test (active standing) on the subjects. The main objective of this study is to evaluate the effectiveness of a structured, individually-tailored, exercise training program in preventing space-induced orthostatic intolerance and its underlying, mainly neural, mechanisms in astronauts.

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Orthostatic intolerance
Blood pressure
Heart rate

Data Information
Data Availability
Archiving in progress. Data is not yet available for this experiment.

Blood lactate
Continuous blood pressure
Heart rate

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Expedition 42 11/10/2014 03/11/2015 121 days
Expedition 43 03/11/2015 06/10/2015 91 days
Expedition 52 06/02/2017 09/02/2017 92 days
Expedition 53 09/02/2017 12/14/2017 102 days

Additional Information
Managing NASA Center
Johnson Space Center (JSC)
Responsible NASA Representative
Johnson Space Center LSDA Office
Project Manager: Jessica Keune
Institutional Support
Italian Space Agency (ASI)