Along with their scheduled on-orbit training program, the subjects perform a structured, individually-tailored, treadmill exercise training program. This program is planned by the PI on the basis of a pre-flight incremental treadmill exercise test, using the TRIMPi (individualized Training IMPulse) training methodology. The experiment requires the execution of a pre- and post-flight orthostatic tolerance test (active standing) on the subjects. The main objective of this study is to evaluate the effectiveness of a structured, individually-tailored, exercise training program in preventing space-induced orthostatic intolerance and its underlying, mainly neural, mechanisms in astronauts.
At L – 65 (± 5), the subject is required to perform a progressive exercise test on a treadmill to volitional fatigue with recording of Heart Rate (HR) and blood lactate levels for determination of individualized TRIMPi, in order to plan the individually-tailored exercise training program. In the same timeframe, the subject is required to undergo an Orthostatic Tolerance test consisting of 10 minutes of supine rest followed by 20 minutes of unaided standing during which blood pressure and heart rate will be continuously and non- invasively recorded. An additional orthostatic test is desired, but not mandatory, at L – 4 (± 3).
At R + 6 (± 4), the subject is required to undergo an Orthostatic tolerance test consisting of 10 minutes supine rest followed by 20 minutes of unaided standing during which blood pressure and heart rate will be continuously and non- invasively recorded as done pre-flight.
In flight, the subject is required to perform the structured exercise training program planned before flight on the treadmill, according to the schedule foreseen for their usual physical activity on board, which is assumed consists in approximately two hour per day (one in the morning and one in the afternoon). During the aerobic exercise sessions, the astronaut is required to wear a heart rate monitor capable to store HR values; data will be downloaded to the ground and analyzed by the PI using a dedicated software. The subject should record HR during training sessions to be performed on alternate days for the last two months before re-entry.
This is an international experiment. NASA does not currently have an agreement with international space partners to archive their data in the LSDA.