Skip to page content Mission Information

EXPERIMENT INFORMATION

Morphological and Biochemical Examination of Heart Tissue: I. Effects of Microgravity on the Myocardial Fine Structure of Rats Flown on Cosmos 1887 - Ultrastructure Studies (COS 1887-18)
Principal Investigator
Research Area:
Cardiovascular physiology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

Vascular deconditioning, which is an important medical problem, is recognized as one of the key concerns of space flight research. This loss of physiological performance of the circulatory system is accompanied by disuse muscle atrophy triggered by the reduced functional load of the musculoskeletal system in the microgravity environment. Animal models are often used to examine disuse atrophy because they are more amenable to morphological and biomedical research needed to unravel the mechanisms of muscle breakdown. Using these models, one could design preventive countermeasures. The present study seeks to expand this previous research.


++ -- View more

Publications
Philpott, D.E. et al.: Morphological and Biochemical Examination of Cosmos 1887 Rat Heart Tissue: Part I - Ultrastructure. FASEB Journal, vol. 4, no. 1, 1990, pp. 73-78.

Philpott, D.E. et al.: Morphological and Biochemical Examination of Heart Tissue: I. Effects of Microgravity on the Myocardial Fine Structure of Rats Flown on Cosmos 1887 - Ultrastructure Studies. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 297-313.

Philpott, D.E. et al.: Ultrastructure and Cyclic AMP Medicated Changes in Heart Muscle Under Altered Gravity Conditions. Journal of Molecular and Cellular Cardiology, vol. 19, no. IV, 1987, p. S61.

Keywords
Atrophy
Muscles
Mitochondria, heart
Myocardium
Glycogen

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Count, Mitochondria, atrial myofiber, heart, rat, Electron micrography
Density, Mitochondria, heart, rat, Electron microscopy, film (counts per volume)
Glycogen: atrial myofiber
Lipid accumulation: myocardium
Morphology, Capillaries, myocardium, ventricle, heart, rat, Electron microscopy (descriptive)
++ -- View more

Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1887-1.1
Protocol / Approach
Hardware Items