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EXPERIMENT INFORMATION

Morphological and Biochemical Examination of Heart Tissue: II. Cellular Distribution of Cyclic AMP-Dependent Protein Kinase Regulatory Subunits in Heart Muscle of Rats Flown on Cosmos 1887 (COS 1887-20)
Principal Investigator
Research Area:
Cardiovascular physiology
Endocrinology
Species Studied
Scientific Name: Rattus norvegicus Species: Rat Strain: Wistar

Description
Objectives:

The study was undertaken in order to gain insight into the mechanistic aspects of cardiac changes that both animals and humans undergo as a consequence of space travel. A number of physiologic changes, attributed to space travel conditions in experimental animals and humans, can be the consequence of increased circulating levels of catecholamine hormones. In this study, the cellular compartmentalization and biochemical localization of regulatory subunits (R-subunits) of cyclic AMP-dependent protein kinase (cAPK) of ventricle heart tissue obtained from space-flown rats were determined.


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Publications
Mednieks, M.I. et al.: Cyclic-AMP Receptor Proteins in Heart Muscle of Rats Flown on Cosmos 1887. Aviation, Space, and Environmental Medicine, vol. 62, 1991, pp. 947-952.

Mednieks, M.I. et al.: Morphological and Biochemical Examination of Heart Tissue: II. Cellular Distribution of Cyclic Amp-Dependent Protein Kinase Regulatory Subunits in Heart Muscle of Rats Flown on Cosmos 1887. Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 1887. J.P. Connolly, R.E. Grindeland, and R.W. Ballard, eds., NASA TM-102254, 1990, pp. 315-329.

Keywords
Cyclic AMP-dependent protein kinases
Myocardium
Cyclic AMP (cAMP) receptor protein
Cyclic AMP (cAMP)
Adenylate cyclase

Data Information
Data Availability
Archive is complete. No data sets are available for this experiment. Please Contact LSDA if you know of available data for this investigation.

Parameters
Content, Protein, myocardium, ventricle, heart, rat, Biochemistry
Distribution, Cyclic AMP (cAMP), ventricle, heart, rat, Histochemistry, microscopy
Distribution, Protein pattern, myocardium, ventricle, heart, rat, Gel Electrophoresis
Morphology, Myocardium, auricle, heart, rat, Light microscopy, computer assisted metrics (area, volume, density)
Morphology, Myocardium, ventricle, heart, rat, Electron microscopy, immunogold (quantitate regulatory subunits of c-protein kinase, c-APK)
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Mission/Study Information
Mission Launch/Start Date Landing/End Date Duration
Cosmos 1887 09/29/1987 10/11/1987 13 days

Additional Information
Co-Investigators
Managing NASA Center
Ames Research Center (ARC)
Responsible NASA Representative
Ames Research Center LSDA Level 3
Project Manager: Helen Stewart
Institutional Support
National Aeronautics and Space Administration (NASA)
Alternate Experiment Name
C1887-1.2
Protocol / Approach
Hardware Items